{"id":3327,"date":"2021-09-07T11:39:37","date_gmt":"2021-09-07T11:39:37","guid":{"rendered":"https:\/\/silfrohn.pt\/?p=3327"},"modified":"2026-09-14T08:50:52","modified_gmt":"2026-09-14T08:50:52","slug":"despiste-da-resistencia-a-multi-drogas-altdeutscher-schaferhund-mdr1","status":"publish","type":"post","link":"https:\/\/caes.silfrohn.pt\/en-2\/despiste-da-resistencia-a-multi-drogas-altdeutscher-schaferhund-mdr1\/","title":{"rendered":"Despiste da resist\u00eancia a multi drogas- Altdeutscher Sch\u00e4ferhund – MDR1"},"content":{"rendered":"

O que \u00e9 a MDR-1?<\/h2><\/div><\/div><\/div><\/div><\/div>

A resist\u00eancia multi drogas (Multi-Drug-Resistance) \u00e9 devido a uma anomalia do gene com o mesmo nome. Quando os c\u00e3es s\u00e3o afetados apresentam sensibilidade aumentada a certos medicamentos podendo ir at\u00e9 \u00e0 intoxica\u00e7\u00e3o e morte.<\/p>\n<\/div><\/div><\/div><\/div><\/div>

Epidemiologia<\/h2><\/div><\/div><\/div><\/div><\/div>

Inicialmente descoberto nos colleys, esta anomalia foi de seguida identificada em 10 outras ra\u00e7as (pastor alem\u00e3o, pastor australiano, pastor branco suisso, colley, border colley, border collie, english shepherd, longhaired shepherd Mac Nab, old english sheepdog, shetland, silken windhound, waller).<\/p>\n

O modo de transmiss\u00e3o \u00e9 autoss\u00f3mico co-dominante (veja quadro)<\/p>\n<\/div><\/div><\/div><\/div><\/div>

\n
\n\n\n\n\n\n\n
MDR-1\u00a0<\/span><\/b>\u00a0<\/span><\/th>\nM\u00e3e<\/p>\n

saud\u00e1vel<\/p>\n

(+\/+)<\/th>\n

M<\/span><\/b>\u00e3e<\/span><\/b>\u00a0<\/span><\/b><\/p>\n

Por<\/span><\/b>tadora<\/span><\/b><\/p>\n

(+\/-)<\/span><\/b><\/th>\n<\/tr>\n<\/thead>\n

P<\/span><\/b>ai<\/span><\/b> saud\u00e1vel<\/span><\/b>\u00a0<\/span><\/b><\/p>\n

(++)<\/span><\/b><\/td>\n

Sa<\/span>ud\u00e1vel<\/span>\u00a0<\/span><\/p>\n

(+ \/ +)\u00a0<\/span><\/td>\n

Port<\/span>ador<\/span>\u00a0<\/span><\/p>\n

(+ \/ -)\u00a0<\/span>\u00a0<\/span><\/td>\n<\/tr>\n

P<\/span><\/b>ai\u00a0<\/span><\/b>portador<\/span><\/b> <\/b><\/p>\n

(+\/-) <\/span><\/b><\/td>\n

Portador<\/p>\n

(+\/-)<\/td>\n

Doente<\/p>\n

(-\/-)<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

Os<\/span>\u00a0<\/span>heterozigoticos<\/span>\u00a0(<\/span>portadores<\/span>)\u00a0<\/span>s\u00e3o<\/span>\u00a0<\/span>menos<\/span>\u00a0<\/span>sensiveis, <\/span>podem<\/span>\u00a0no\u00a0<\/span>entanto<\/span>\u00a0<\/span>apresentar<\/span>\u00a0<\/span>sinais<\/span>\u00a0<\/span>cl\u00ednicos<\/span> de <\/span>intoxica\u00e7\u00e3o<\/span>\u00a0de\u00a0<\/span>menor<\/span>\u00a0amplitude\u00a0<\/span>ou<\/span> com doses <\/span>mais<\/span>\u00a0<\/span>elevadas<\/span>\u00a0dos\u00a0<\/span>medicamentos<\/span>.\u00a0<\/span>\u00a0<\/span><\/p>\n<\/div>\n<\/div><\/div><\/div><\/div>

Quais s\u00e3o os sinais cl\u00ednicos?<\/h2><\/h1><\/div><\/div><\/div><\/div><\/div>

No mundo existem 11 ra\u00e7as de c\u00e3es onde est\u00e1 reconhecido a muta\u00e7\u00e3o do gene MDR-1. Desde 2009 nos Estados Unidos foi lan\u00e7ado um despiste em rela\u00e7\u00e3o ao pastor alem\u00e3o e foi demonstrado que 10% dos c\u00e3es apresentavam a muta\u00e7\u00e3o.<\/p>\n

Os n\u00fameros n\u00e3o s\u00e3o atualmente conhecidos na Europa, no entanto algumas intoxica\u00e7\u00f5es j\u00e1 foram reportadas justificando assim o despiste nos Altdeutsche Sch\u00e4ferhunde sendo relacionados com o pastor alem\u00e3o.<\/p>\n

Alguns casos ocorreram com a utiliza\u00e7\u00e3o de medicamentos de medicina veterin\u00e1ria correntes tais que desparasitantes, medica\u00e7\u00e3o para a diarreia, insufici\u00eancia card\u00edaca, os cancros ou tranquilizantes.<\/p>\n

Os sintomas e sinais podem ser dermatol\u00f3gicos, oculares, digestivos, neurol\u00f3gicos ou outros.<\/p>\n

No caso de aparecimento de sinais cl\u00ednicos inabituais no seu c\u00e3o ap\u00f3s administra\u00e7\u00e3o de um medicamento recorra urgentemente ao veterin\u00e1rio.<\/p>\n<\/div><\/div><\/div><\/div><\/div>

\n
\n

Lis<\/span><\/i>ta de\u00a0<\/span><\/i>medica\u00e7\u00e3o<\/span><\/i>\u00a0(<\/span><\/i>n\u00e3o<\/span><\/i>\u00a0<\/span><\/i>exaustiva<\/span><\/i>)\u00a0<\/span><\/i>em<\/span><\/i>\u00a0qu<\/span><\/i>e<\/span><\/i>st\u00e3o\u00a0<\/span><\/i>na<\/span><\/i>\u00a0MDR-1<\/span><\/i>:<\/span><\/i>\u00a0<\/span><\/i>\u00a0<\/span><\/p>\n\n\n\n\n\n
Substrato da prote\u00edna<\/th>\nInibidor da prote\u00edna<\/th>\nIndutor da prote\u00edna<\/th>\n<\/tr>\n<\/thead>\n
Ac\u00e9promazine<\/span>\u00a0<\/span><\/p>\n

 <\/p>\n

Amitript<\/span>i<\/span>llin<\/span>a<\/span>\u00a0<\/span><\/p>\n

Amoxicillin<\/span>a<\/span>\u00a0<\/span><\/p>\n

Butorphanol<\/span>\u00a0<\/span><\/p>\n

C\u00e9tirizin<\/span>a<\/span>\u00a0<\/span><\/p>\n

Ciclosporin<\/span>a<\/span>\u00a0<\/span><\/p>\n

Cim\u00e9tidin<\/span>a<\/span>\u00a0<\/span><\/p>\n

Ciprofloxacin<\/span>a<\/span>\u00a0<\/span><\/p>\n

Corticost<\/span>eroides<\/span>\u00a0<\/span><\/p>\n

Dexam\u00e9tason<\/span>a<\/span>\u00a0<\/span><\/p>\n

Digoxin<\/span>a<\/span>\u00a0<\/span><\/p>\n

Domp<\/span>e<\/span>ridon<\/span>a<\/span>\u00a0<\/span><\/p>\n

Doxorubicin<\/span>a<\/span>\u00a0<\/span><\/p>\n

Dox<\/span>i<\/span>c<\/span>i<\/span>clin<\/span>a<\/span>\u00a0<\/span><\/p>\n

Emodepsid<\/span>a<\/span>\u00a0<\/span><\/p>\n

Imatinib<\/span>\u00a0<\/span><\/p>\n

Itraconazol<\/span>\u00a0<\/span><\/p>\n

Ivermectin<\/span>a<\/span>\u00a0<\/span>\u00a0<\/span><\/p>\n

C<\/span>etoconazol<\/span>\u00a0<\/span><\/p>\n

Lop<\/span>a<\/span>ramid<\/span>a<\/span>\u00a0<\/span><\/p>\n

M<\/span>et<\/span>adon<\/span>a<\/span>\u00a0<\/span><\/p>\n

M<\/span>etotrexato<\/span>\u00a0<\/span><\/p>\n

M<\/span>e<\/span>t<\/span>i<\/span>lprednisolon<\/span>a<\/span>\u00a0<\/span><\/p>\n

M<\/span>e<\/span>toclopramid<\/span>a<\/span>\u00a0<\/span><\/p>\n

Milb<\/span>e<\/span>m<\/span>i<\/span>cin<\/span>a<\/span>\u00a0<\/span><\/p>\n

Mitoxantron<\/span>a<\/span>\u00a0<\/span><\/p>\n

Mor<\/span>f<\/span>in<\/span>a<\/span>\u00a0<\/span><\/p>\n

Moxidectin<\/span>a<\/span>\u00a0<\/span><\/p>\n

F<\/span>\u00e9nobarbital<\/span>\u00a0<\/span><\/p>\n

Fenitoina<\/span>\u00a0<\/span><\/p>\n

Prednisolon<\/span>a<\/span>\u00a0<\/span><\/p>\n

Ranitidin<\/span>a<\/span>\u00a0<\/span><\/p>\n

Rifampicin<\/span>a<\/span>\u00a0<\/span><\/p>\n

S\u00e9lamectin<\/span>a<\/span>\u00a0<\/span><\/p>\n

Spinosad<\/span>\u00a0<\/span><\/p>\n

Es<\/span>piram<\/span>i<\/span>cin<\/span>a<\/span>\u00a0<\/span><\/p>\n

Tamoxif<\/span>e<\/span>ne<\/span>o<\/span>\u00a0<\/span><\/p>\n

T<\/span>e<\/span>trac<\/span>i<\/span>clin<\/span>a<\/span>\u00a0<\/span><\/p>\n

Triamcinolon<\/span>a<\/span>\u00a0<\/span><\/p>\n

Vinblastin<\/span>a<\/span>\u00a0<\/span><\/p>\n

Vincristin<\/span>a<\/span>\u00a0<\/span><\/td>\n

Amitript<\/span>ilina<\/span>\u00a0<\/span><\/p>\n

 <\/p>\n

Bromocriptin<\/span>a<\/span>\u00a0<\/span><\/p>\n

Carbamaz<\/span>e<\/span>pin<\/span>a<\/span>\u00a0<\/span><\/p>\n

Ciclosporin<\/span>a<\/span>\u00a0<\/span><\/p>\n

C<\/span>i<\/span>proheptadin<\/span>a<\/span>\u00a0<\/span><\/p>\n

Doxorubicin<\/span>a<\/span>\u00a0<\/span><\/p>\n

Fentan<\/span>i<\/span>l<\/span>\u00a0<\/span><\/p>\n

Fluox<\/span>e<\/span>tin<\/span>a<\/span>\u00a0<\/span><\/p>\n

Fluvoxamin<\/span>a<\/span>\u00a0<\/span><\/p>\n

H<\/span>i<\/span>rox<\/span>i<\/span>zin<\/span>a<\/span>\u00a0<\/span><\/p>\n

Itraconazol<\/span>\u00a0<\/span><\/p>\n

Ivermectin<\/span>a<\/span>\u00a0<\/span><\/p>\n

Sumo de\u00a0<\/span>Toranja<\/span>\u00a0<\/span><\/p>\n

Sumo de\u00a0<\/span>Laranja<\/span>\u00a0<\/span><\/p>\n

Ce<\/span>toconazol<\/span>\u00a0<\/span><\/p>\n

L<\/span>e<\/span>vot<\/span>i<\/span>roxin<\/span>a<\/span>\u00a0<\/span><\/p>\n

Lop<\/span>eramida<\/span>\u00a0<\/span><\/p>\n

Loratadin<\/span>a<\/span>\u00a0<\/span><\/p>\n

M<\/span>e<\/span>tadon<\/span>a<\/span>\u00a0<\/span><\/p>\n

Midazolam<\/span>\u00a0<\/span><\/p>\n

Ofloxacin<\/span>a<\/span>\u00a0<\/span><\/p>\n

Om<\/span>e<\/span>prazol<\/span>\u00a0<\/span><\/p>\n

Es<\/span>pironolacton<\/span>a<\/span>\u00a0<\/span><\/p>\n

Tamoxif<\/span>eno<\/span>\u00a0<\/span><\/p>\n

Vinblastin<\/span>a<\/span>\u00a0<\/span><\/p>\n

Vincristin<\/span>a<\/span>\u00a0<\/span><\/td>\n

Dexam<\/span>et<\/span>asone<\/span>a<\/span>\u00a0<\/span><\/p>\n

 <\/p>\n

Millepertuis<\/span>\u00a0<\/span>\u00a0<\/span><\/p>\n

Rifampicin<\/span>a<\/span>\u00a0<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n<\/div><\/div><\/div><\/div>

Como diagnoticar a MDR-1?<\/h2><\/h1><\/div><\/div><\/div><\/div><\/div>

O veterin\u00e1rio ir\u00e1 realizar um esfrega\u00e7o bucal ou an\u00e1lise sangu\u00ednea com encaminhamento para os\u00a0<\/span>centros<\/span>\u00a0de\u00a0<\/span>estudo<\/span>\u00a0<\/span>gen\u00e9tico<\/span> para<\/span>\u00a0proceder\u00a0ao\u00a0exame\u00a0e\u00a0poder\u00a0indicar\u00a0o\u00a0resultado.<\/span><\/p>\n<\/div><\/div><\/div><\/div><\/div>

Qual a posi\u00e7\u00e3o dos clubes da ra\u00e7a Altdeutscher Sch\u00e4ferhund em rela\u00e7\u00e3o \u00e0 MDR-1?<\/h2><\/div><\/div><\/div><\/div><\/div>

Os clubes da ra\u00e7a recomendam a realia\u00e7\u00e3o do teste de despiste por precau\u00e7\u00e3o a todos os donos de Altdeutscher Sch\u00e4ferhund.<\/p>\n<\/div><\/div><\/div><\/div><\/div><\/p>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":1,"featured_media":4103,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_feature_clip_id":0,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_post_was_ever_published":false},"categories":[30,71],"tags":[33,34,35,36,37,38,39,40,41,42,43,45,46,47,48,49,50,51,52,53,54,55,56,57,59,60,61,62,63,64,65,66,67,68,75,69,70,72,73],"class_list":["post-3327","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-pastor-alemao-de-linhagem-antiga","category-saude","tag-altdeustcher-schaferhund","tag-altdeutscher-schaferhund","tag-animais","tag-animals","tag-awesome","tag-brutal","tag-cachorro","tag-caes","tag-cao","tag-ddr","tag-despiste","tag-displasia-do-cotovelo","tag-dog","tag-dogs","tag-elbow-displasia","tag-german-shepperd","tag-mielopatia-degenerativa","tag-nanismo-hipofisario","tag-old-line-german-shepperd","tag-os-nossos-caes","tag-pastor-alemao","tag-pastor-alemao-beleza","tag-pastor-alemao-ddr","tag-pastor-alemao-de-linhagem-antiga","tag-pastor-alemao-show","tag-pastor-alemao-trabalho","tag-pastor-ddr","tag-pastor-de-trabalho","tag-pedigree","tag-quinta-silfrohn","tag-raca","tag-raca-de-cao","tag-rastrei","tag-rastreio","tag-resistencia-multidrogas","tag-resistencia-multidrogas-caninas","tag-saude","tag-silfrohn","tag-wild-life"],"jetpack_sharing_enabled":true,"jetpack_featured_media_url":"https:\/\/i0.wp.com\/caes.silfrohn.pt\/wp-content\/uploads\/2021\/05\/blood-test_tubes-scaled.jpg?fit=2560%2C2525&ssl=1","_links":{"self":[{"href":"https:\/\/caes.silfrohn.pt\/en-2\/wp-json\/wp\/v2\/posts\/3327","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/caes.silfrohn.pt\/en-2\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/caes.silfrohn.pt\/en-2\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/caes.silfrohn.pt\/en-2\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/caes.silfrohn.pt\/en-2\/wp-json\/wp\/v2\/comments?post=3327"}],"version-history":[{"count":1,"href":"https:\/\/caes.silfrohn.pt\/en-2\/wp-json\/wp\/v2\/posts\/3327\/revisions"}],"predecessor-version":[{"id":61059,"href":"https:\/\/caes.silfrohn.pt\/en-2\/wp-json\/wp\/v2\/posts\/3327\/revisions\/61059"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/caes.silfrohn.pt\/en-2\/wp-json\/wp\/v2\/media\/4103"}],"wp:attachment":[{"href":"https:\/\/caes.silfrohn.pt\/en-2\/wp-json\/wp\/v2\/media?parent=3327"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/caes.silfrohn.pt\/en-2\/wp-json\/wp\/v2\/categories?post=3327"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/caes.silfrohn.pt\/en-2\/wp-json\/wp\/v2\/tags?post=3327"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}